Neuroendocrine Mechanisms in Adiposity: An Integrated Approach to the Characterization of Potential Pharmacological Novel Targets Based on Experimental and Clinical Models
- Conditions
- AcromegalyPituitary AdenomaCushing SyndromeHypopituitarismEndocrine DisordersAdiposity
- Registration Number
- NCT06326853
- Lead Sponsor
- IRCCS San Raffaele
- Brief Summary
The goal of this observational study is to evaluate, retrospectively and prospectively, the effect of different hormonal and neuropeptide dysfunctions on the body composition of patients suffering from hypothalamic-pituitary pathologies, and to evaluate the potential beneficial effect of surgical and medical treatments with agonists and antagonists of hypothalamic neuropeptides, currently available, on the development and treatment of adiposity and negative cross-talk between adiposity and muscle/bone tissue
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 200
Obese patients affected and not by hypothalamic-pituitary diseases
- Minor subjects;
- Pregnant and/or breastfeeding women;
- Patients suffering from states of primary and/or acquired immunodeficiencies, and/or serious impairment of general clinical conditions (e.g. metastatic neoplasms; immunosuppressive therapies; worsening/reacerbated/compensated chronic pathologies);
- Patients unable to understand and sign the Informed Consent.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Rate of patients with BMI greater than 30 with hypothalamic-pituitary pathologies retrospective and prospective collection of clinical data between 01/01/2021 and 31/12/2026 The study aims to evaluate, retrospectively and prospectively, the effect of different hormonal and neuropeptide dysfunctions on the body composition of patients suffering from hypothalamic-pituitary pathologies
- Secondary Outcome Measures
Name Time Method