Biomarkers to differentiate asymptomatic bacteriuria into urinary tract infection or colonization requiring treatment

• Conditions: N39.0; Urinary tract infection, site not specified

• Registration Number: DRKS00032772
• Lead Sponsor: niversitätsklinikum Frankfurt

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-10-13
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

Female gender, premenopausal
- Symptomatic, community-acquired, uncomplicated urinary tract infection; defined according to the criteria of the current AWMF guideline (4) BEFORE antibiotic therapy.
- Written informed consent to participate in the study.

Exclusion Criteria

- Evidence of more serious or other urogenital infection including fever, flank pain, renal pelvic palpitation, vaginal discharge, and vaginal pain.
- Pregnancy
- Diabetes mellitus and other relevant metabolic diseases
- Kidney disease
- Taking medications that affect the genitourinary tract
- Immunosuppression

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Differences in metabolome composition between patients with acute symptomatic UTI and healthy subjects.

Secondary Outcome Measures

Name	Time	Method
Difference in intra- and interindividual metabolome composition of the subjects under predefined preanalytical conditions compared to the preanalytical best practice protocol defined as gold standard