Identification of Genetic Causes of Calcific Aortic Valve Disease
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 1,000
- 试验地点
- 2
- 主要终点
- Identification of expression signatures of aortic valve development and calcification in the macroscopically normal and abnormal portions of aortic valves excised during aortic valve replacement.
研究概览
简要总结
This study aims to identify the molecular genetic causes of the variability in development of calcific aortic valve disease in bicuspid and tricuspid aortic valves and their associated aortic dilation.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with a plan to undergo elective aortic valve replacement and/or ascending aortic surgery
排除标准
- •Age < 20 years
- •Unable/unwilling to consent
- •History of aortic valve replacement or transcatheter aortic valve replacement (TAVR)
- •History of endocarditis
- •History of rheumatic fever
- •History of chest radiotherapy
- •History of organ transplant
结局指标
主要结局
Identification of expression signatures of aortic valve development and calcification in the macroscopically normal and abnormal portions of aortic valves excised during aortic valve replacement.
时间窗: 8 years
We will take a portion of the aortic valve and/or aortic tissue that is routinely excised for aortic valve or aortic replacement for expression analyses and generation of fibroblast cell lines. In collaboration with the Department of Pathology, we have established methods to take sufficient "normal" and abnormal tissue while allowing formal routine pathological evaluation. All tissue samples for expression analysis will be transported in iced RNALater and later frozen in a -80°C research freezer, prior to next generation sequencing. We may use tissue samples to develop cell lines for indefinite use.
次要结局
未报告次要终点
研究者
Simon Robson
Professor of Anaesthesia
Beth Israel Deaconess Medical Center