Effect of Bariatric Surgery on Cognition, Genetics and Lifestyle
- Conditions
- Obesity, Morbid
- Registration Number
- NCT02085369
- Lead Sponsor
- Uppsala University
- Brief Summary
Obesity bariatric surgery patients usually lose more than 50% of their former obesity within a relatively short time (\~ 2 years). There is still a lack of knowledge about underlying psychological and biological mechanisms of decline in body weight. The intention of this project is to investigate whether bariatric surgery is associated with patients' cognitive ability, lifestyle and/or gene expression and metabolomics.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
- First bariatric surgery
- More than one surgery
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes in gene expression profile (a.o. FTO, BDNF) following a standardized meal (before vs. after surgery) 1 year Gene expression profiling (whole genome analysis, with first interest in FTO and BDNF expression) to assess changes in gene expression before vs. after surgery, and to associate gene expression with weight loss after surgery
- Secondary Outcome Measures
Name Time Method The effect of bariatric surgery on cognitive functioning (inhibitory control, selective attention) Measures 1 y, 2 y, and 5 y after surgery. No-Go go task (to assess inhibitory control) and Stroop tasks (to assess selective attention) will be measured to assess change in these cognitive functions before vs. after surgery, and to associate cognitive functioning with weight loss after surgery
Trial Locations
- Locations (1)
Uppsala University Hospital
🇸🇪Uppsala, Sweden