MRI Biomarkers of Risk in Sedentary and Exercise Trained Humans
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cerebrovascular Circulation
- Sponsor
- University of Wisconsin, Madison
- Enrollment
- 71
- Locations
- 1
- Primary Endpoint
- White Matter Hyperintensity Volume
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
The overall goal of observational study is to examine the age-related and habitual exercise training status-related differences in structural and functional changes in the human brain, detected by magnetic resonance (MR) imaging.
Detailed Description
Normal aging reduces cerebral blood flow, brain volume, and cognitive function, thereby increasing the risk of dementia or Alzheimer's disease. Aging is associated with increased white matter hyperintensities (WMH) and appears to alter functional connectivity within the brain both of which associated with cognitive function (references). Observational studies suggest that regular physical activity is associated with improved cognitive function and higher cerebral blood flow 1,2. However, it is unknown if aging or exercise training status alters the structural and functional biomarkers that are predictive of cognitive decline. Thus, the overall goal of this project is to examine the age-related and exercise training status-related differences in structural and functional changes in the brain, detected by magnetic resonance (MR) imaging. 1. To determine if white matter hyperintensities on MRI scans of the brain are altered by aging and exercise training status. 2. To determine the interaction of aging and habitual physical activity on functional connectivity in the brain.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Between 18-35 or 55-75
- •Body mass index \<34 kg/m2
- •Physically active (exercise more than 3 times per week for at least 30 min) or sedentary (no formal exercise over 1 hour per week)
Exclusion Criteria
- •Current smoker
- •History or evidence of: hepatic disease, renal disease, hematological disease, peripheral vascular disease, stroke/neurovascular disease, diabetes, hypertension
- •Part of a vulnerable population (e.g. pregnant women, prisoner, individuals lacking capacity to consent, etc.)
Outcomes
Primary Outcomes
White Matter Hyperintensity Volume
Time Frame: 60 minutes
Utilize an MRI to measure brain volume when participant is at rest
Secondary Outcomes
- Default Mode Network Connectivity(60 minutes)
- Middle Cerebral Artery Blood Flow Scan(60 minutes)