Effect of inhaled ATP and hypo-osmolar solutions on blood ATP metabolites and cough in refractory chronic cough and healthy volunteers

Manchester University NHS Foundation Trust0 个研究点目标入组 40 人开始时间: 2021年4月13日最近更新: 2022年8月5日

试验速览

暂无简介。

•1. Males and females 18 - 80yrs, inclusive
•2. Non-smokers; ex-smokers <20 pack years, >6 months abstinence
•3. Healthy Volunteers:
•3.1. No clinically relevant abnormalities based on the medical history, physical examination, vital signs
•3.2. No history of current or significant past respiratory disease, specifically a diagnosis of asthma
•3.3. Spirometry within normal limits
•4. Chronic Cough Patients :
•4.1. Have a refractory chronic cough as defined by BTS/ERS guidelines
•4.2. No evidence of asthma during clinical evaluation of chronic cough e.g. elevated FeNO, bronchodilator reversibility, abnormal methacholine responsiveness

•1. Any condition that may increase airway/circulating levels of ATP/adenosine e.g. chronic cardiac failure, chronic hypoxia, and vigorous exercise
•2. Pregnancy or Breastfeeding
•3. Upper or lower respiratory tract infection or significant change in pulmonary status within 4 weeks of enrolment.
•4. Any therapy that may modulate cough (e.g. ACE inhibitors, opioids, gabapentin)
•5. Patients with asthma

发起方