ATP in the Airways and Plasma in Chronic Cough

Manchester University Foundation Trust0 个研究点目标入组 70 人开始时间: 2019年11月29日最近更新: 2024年7月15日

适应症

试验速览

暂无简介。

•Chronic cough patients:
•1. Aged 18-80 years
•2. Have idiopathic chronic cough as defined by BTS guidelines.
•3. Non-smokers or ex-smokers with =10 pack years of smoking and >6 months abstinence
•4. No clinically relevant abnormalities based on the medical history, physical examination, vital signs or significant past respiratory disease, except for chronic cough
•Healthy volunteers:
•5. Aged 45-80 years
•6. Spirometry within normal limits
•7. Non-smokers or ex-smokers with =10 pack years of smoking and >6 months abstinence
•8. No clinically relevant abnormalities based on the medical history, physical examination, vital signs or significant past respiratory disease

•1. Have received any medications likely to modulate cough within 2 weeks of enrolment. They can be included if willing/able to discontinue these for the duration of the study.
•2. Currently taking ACE inhibitors
•3. Any condition that may increase circulating levels of ATP/ATP metabolites e.g. chronic cardiac failure, chronic hypoxia, vigorous exercise in the last 48 h, or regular vigorous exercise, such as professional sports or competitive training
•4. Pregnant or breastfeeding
•5. FEV1/FVC <70%
•6. Recent history of upper or lower respiratory tract infection or significant change in pulmonary status within 4 weeks of enrolment
•7. Other severe, acute, or chronic medical or psychiatric condition that may increase the risk associated with trial participation or may interfere with the interpretation of trial results

发起方

Manchester University Foundation Trust