Are ATP levels in the blood and airways higher in people with chronic cough?

Not Applicable

• Conditions: Chronic cough; Respiratory

• Registration Number: ISRCTN52011944
• Lead Sponsor: Manchester University Foundation Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-11-29
• Last Update Posted: 15 July 2024
• Study Completion: 2025-01-31

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Chronic cough patients:
1. Aged 18-80 years
2. Have idiopathic chronic cough as defined by BTS guidelines.
3. Non-smokers or ex-smokers with =10 pack years of smoking and >6 months abstinence
4. No clinically relevant abnormalities based on the medical history, physical examination, vital signs or significant past respiratory disease, except for chronic cough

Healthy volunteers:
5. Aged 45-80 years
6. Spirometry within normal limits
7. Non-smokers or ex-smokers with =10 pack years of smoking and >6 months abstinence
8. No clinically relevant abnormalities based on the medical history, physical examination, vital signs or significant past respiratory disease

Exclusion Criteria

1. Have received any medications likely to modulate cough within 2 weeks of enrolment. They can be included if willing/able to discontinue these for the duration of the study.
2. Currently taking ACE inhibitors
3. Any condition that may increase circulating levels of ATP/ATP metabolites e.g. chronic cardiac failure, chronic hypoxia, vigorous exercise in the last 48 h, or regular vigorous exercise, such as professional sports or competitive training
4. Pregnant or breastfeeding
5. FEV1/FVC <70%
6. Recent history of upper or lower respiratory tract infection or significant change in pulmonary status within 4 weeks of enrolment
7. Other severe, acute, or chronic medical or psychiatric condition that may increase the risk associated with trial participation or may interfere with the interpretation of trial results

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
evel of ATP in bronchial lavage fluid (BALF) measured using validated ATP assays at visit 1 and visit 2