ATP leves and P2R expression in acut lung inflammation such as ARDS und pneumonia

Recruiting

• Conditions: J45.9; ARDS (acute respiratory distress syndrome)pneumonia; J18.0; J80; J44; Bronchopneumonia, unspecified; Adult respiratory distress syndrome; Asthma, unspecified; Other chronic obstructive pulmonary disease

• Registration Number: DRKS00003550
• Lead Sponsor: Abteilung PneumologieUniversitätsklinikum Freiburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-03-13
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

a) diagnosis of pneumonia with diagnostic indication to perform bronchoscopy with BAL

b) intubated patients with following clinical and radiological criteria of ARDS and indication to perform bronchoscopy with BAL:

- acute onset of respiratory worsening within 38 to 72 hours
- bilateral infiltrats in chest x-ray
- PaO2/FiO2 <300mmHg
- No suspected left arterial pressure

c) Healthy subjects: Nomal values in laboratory and lung function testing

Exclusion Criteria

in a) and b) NO clinical indication to perform bronchoscopy

a) in patients with pneumonia:
- severe heart failure
- lung edema
- pulmonary infections like tuberculosis, influenca pneumonia, swine influenca
- bronchial carcinoma
- chemotherapy during last 2 weeks

b) in ARDS-patients:
-Suspected elevated left arterial pressure
- pulmonary infections like tuberculosis, influenca pneumonia, swine influenca
- bronchial carcinoma
- chemotherapy during last 2 weeks

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
ATP-level in BAL-fluid

Secondary Outcome Measures

Name	Time	Method
P2R-expression at BALF-cells blood cells