Transpulmonary Gradient After Cardiac Surgery Under Cardiopulmonary Bypass

• Conditions: Acute Respiratory Distress Syndrome After Cardiac Surgery Under Cardiopulmonary Bypass

• Registration Number: NCT01723930
• Lead Sponsor: University Hospital, Strasbourg, France

Brief Summary

Get a better understanding of the pathophysiological processes of acute respiratory failure following cardiopulmonary bypass to initiate timely therapies targeted on a cell line.

Demonstrate that there is a relationship between increased transpulmonary gradients of inflammation biomarkers (sRAGE, sICAM-1, SPB, PAI-1, ROS) and pulmonary vascular resistance on the one hand and alveolo-capillary gas exchange on the other hand after cardiac surgery under cardiopulmonary bypass.

Detailed Description

Not available

Study Timeline

• Status Verified: 2012-11
• Study First Submitted: 2012-11-06
• Study First Submitted QC: 2012-11-07
• Last Update Submitted: 2012-11-07
• Study First Posted: 2012-11-08
• Last Update Posted: 2012-11-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• Patient man or woman > 18 y.o.

• Patient has signed informed consent prior to the study

• Patient affiliated to a social security administration

• Patient operated on for cardiac surgery at the University Hospital of Strasbourg.

• Patient at high risk for postoperative respiratory failure defined by a SLIP score (Kor et al.) ≥ 22 Kor:

  • High-risk cardiac intervention under cardiopulmonary bypass (19 pts)
  • COPD (10 pts)
  • Diabetes (6 pts)
  • gastroesophageal reflux (7 pts)
  • Alcohol abuse (11 pts)

• Scheduled use of a pulmonary artery catheter and a left atrial catheter

Exclusion Criteria

• Inability to obtain informed consent from the patient and / or unable to give informed patient information (difficulty understanding ...)
• Urgent surgery (<24h)
• Acute heart failure
• Patient ventilated preoperatively
• Allergy to Latex
• Persons deprived of liberty or under judicial protection
• Patient placed under guardianship
• Pregnancy
• Breastfeeding

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
transpulmonary gradients of inflammation biomarkers (sRAGE, sICAM-1, SPB, PAI-1, ROS) and pulmonary vascular resistance	during the surgery	Demonstrate that there is a relationship between increased transpulmonary gradients of inflammation biomarkers (sRAGE, sICAM-1, SPB, PAI-1, ROS) and pulmonary vascular resistance on the one hand and alveolo-capillary gas exchange on the other hand after cardiac surgery under cardiopulmonary bypass.

Trial Locations

Locations (1)

University Hospital; 🇫🇷 Strasbourg, Alsace, France