The Predictive Effect of the Inflammatory Response on the Evacuation of Mechanical Ventilation and the Mechanism

• Conditions: Systemic Inflammatory Response Syndrome; Ventilator Weaning

• Registration Number: NCT02820090
• Lead Sponsor: Beijing Chao Yang Hospital

Brief Summary

Infection and trauma take a important role in the acute respiratory failure.There are different causes and degrees of inflammatory reaction in the critically ill patient. The inflammatory reaction should also affect patients on mechanical ventilation dependence with body physiological response and disease prognosis in patients. Therefore, the investigators hypothesize that inflammation may have an important role in the prediction of weaning from mechanical ventilation.

Detailed Description

In the process of mechanical ventilation, the patients were divided into two groups according to the failure of spontaneous breathing test and spontaneous breathing test.In the index of predicting mechanical ventilation, the investigators will take the index of inflammatory response, the function index of diaphragm and the amount of exhaled CO2 into account to reduce the failure rate of mechanical ventilation.

Study Timeline

• Study Start: 2014-05
• Study First Submitted: 2016-05-31
• Status Verified: 2016-06
• Study First Submitted QC: 2016-06-29
• Last Update Submitted: 2016-06-29
• Study First Posted: 2016-06-30
• Last Update Posted: 2016-06-30
• Primary Completion: 2017-04
• Study Completion: 2017-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• oral, nasal tracheal intubation and mechanical ventilation in patients with respiratory failure
• mechanical ventilation time over than 48 hours
• Glasgow score greater more than or equal to 13 points

Exclusion Criteria

• Aged less than 14 years or more than 80 years old
• patients with neuromuscular disease
• pure heart failure pulmonary edema patients
• patients with tracheotomy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The relationship between mechanical ventilation of ventilator and inflammatory response	January 2014 to December 2016	Through the study of mechanical ventilation weaning success and failure of patients with respiratory physiological indicators, blood, urine related inflammatory indicators, analysis of the relationship between inflammatory response and mechanical ventilation weaning.The test indicators include C- reactive protein, tumor necrosis factor and some interleukin for related.

Secondary Outcome Measures

Name	Time	Method
The relationship between diaphragm movement function and weaning from mechanical ventilation	January 2016 to December 2017	To study the relationship between the inflammatory response and the contractile function of diaphragm, which is helpful to judge the effect of inflammatory factors on the evacuation of mechanical ventilation.
the output of CO2	January 2016 to December 2017