inflammatory profile following nebulization of hypertonic saline as prophylaxis of VAP

Not Applicable

• Conditions: Ventilatory Associated Pneumonia.; Aspiration pneumonia (due to): NOS, food, (regurgitated) gastric secretions, milk, vomit; J67-J70

• Registration Number: IRCT201202169045N1
• Lead Sponsor: Tehran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

inclusion criteria: intubation period less than 24 hour, no clinical and imaging manifestation of pneumonia
exclusion criteria: pulmonary infection; Acute physiology and chronic health evaluation II score II>25; active infection in admission; evidence of infection in chest X ray; immune deficiency; prescribe of high dose cortocosteroid (more than 300mg hydrocortisone); advanced cancer.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pneumonia. Timepoint: 0, 48, 72, 120 and 144 hour after start of study. Method of measurement: physical exam,chest x ray, culture of tracheal secretion.

Secondary Outcome Measures

Name	Time	Method
evel of Interlukin- 6 levelof trachea secretions and blood. Timepoint: 0, 48,72,120 and 144 hour after start of study. Method of measurement: ELIZA.