Volume versus pressure controlled ventilation in liver recipients
Not Applicable
- Conditions
- Health Condition 1: K720- Acute and subacute hepatic failureHealth Condition 2: K721- Chronic hepatic failure
- Registration Number
- CTRI/2019/12/022456
- Lead Sponsor
- Amrita Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Elective adult patients for liver transplant surgery
Exclusion Criteria
Patients in ALF
Patients in early pulmonary oedema
Documented Hepato-Pulmonary Syndrome
History of previous lung surgery
Patients with obvious thoracic wall abnormalities and
Refusal to participate
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare Alveolar to Arterial oxygen pressure gradient (A-a) DO2 between two ventilator strategies (volume controlled versus pressure controlled ventilation) in patients undergoing elective adult liver transplantTimepoint: 1. T0 Pre-induction <br/ ><br>2. T1 10 m postintubation <br/ ><br>3. T2 application of <br/ ><br> retractors <br/ ><br>4. T3 start of anhepatic phase <br/ ><br>5. T4 10m after reperfusion <br/ ><br>6. T5 End of surgery <br/ ><br>7. T6 Post extubation
- Secondary Outcome Measures
Name Time Method To asess <br/ ><br>1. Arterial to End Tidal Carbon Dioxide pressure gradient <br/ ><br>2. Peak airway pressure (Paw) <br/ ><br>3. Dynamic compliance (Cdyn) <br/ ><br>4. P/F ratio. <br/ ><br>Timepoint: T0 Pre-induction <br/ ><br>2. T1 10 m postintubation <br/ ><br>3. T2 application of <br/ ><br> retractors <br/ ><br>4. T3 start of anhepatic phase <br/ ><br>5. T4 10m after reperfusion <br/ ><br>6. T5 End of surgery <br/ ><br>7. T6 Post extubation