Implications of Different Analgesic Models on Inflammatory Markers After Laparoscopic Cholecystectomy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 110
- 试验地点
- 1
- 主要终点
- postoperative level of ACTH hormone
研究概览
简要总结
Postoperative abdominal and shoulder pain that are experienced in patients undergoing laparoscopic cholecystectomy (LC) is significant. Although it is generally less sever than post open cholecystectomy pain, it still causes an avoidable distress in the first 24 hours postoperatively
详细描述
The incidence of pain after laparoscopy may be as high as 36 to 63 percent and is attributed to the carbon dioxide gas (CO2) used to induce pneumo-peritoneum1.
The residual part of CO2 remains in the peritoneal cavity for several days after the operation and causes stretching of the phrenic nerve endings, local hypothermia, and diaphragmatic irritation by carbonic acid formation
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients scheduled for Laparoscopic cholecystectomy.
- •Age spectrum of 18 - 55 years
- •ASA I, II
- •Have no comorbid chronic medical diseases
排除标准
- •Patients with co morbid medical diseases
- •Age outside the specified range
- •Acute inflammation of the gall bladder
- •Critically ill patient
- •Emergency operations
- •Patient refusal
研究组 & 干预措施
bupivacaine group
干预措施: Bupivacaine (Drug)
bupivacaine + morphine
干预措施: Bupivacaine + morphine (Drug)
bupivacaine + morphine + ketamine
干预措施: Bupivacaine + morphine + ketamine (Drug)
isotonic saline
干预措施: isotonic saline (Drug)
结局指标
主要结局
postoperative level of ACTH hormone
时间窗: 6 hours
a stress marker that increase with pain and surgery
次要结局
- VISUUEAL ANALOGE SCORE(24 hours)