“Study of attenuation of the hemodynamic response to laryngoscopy and endotracheal intubation comparing oral Ivabradine and oral Clonidine - A Randomized control study “
试验速览
- 阶段
- Unknown
- 状态
- 尚未招募
- 发起方
- 入组人数
- 98
- 试验地点
- 1
- 主要终点
- To the best of literature . There is no study evaluating the hemodynamic attenuation of laryngoscope
研究概览
简要总结
The background of the study is that previously a tablet Ivabradine and Tablet Clonidine have been used in attenuation of laryngoscopic response on separate study for intubation response . And it was found with less or no side effects . And the purpose is to compare Tablet Ivabradine and Tablet clonidine during laryngoscope and to find which is better and stable
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant, Investigator, Outcome Assessor and Date-entry Operator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Patient should be of age 18-60 yrs.
- •Patient to get fit under ASA PS I and II Patient should undergo Elective non cardiac surgery under General Anesthesia.
排除标准
- •Patient who refused to give consent for study.
- •Patient with known hypersensitivity to these study drugs.
- •Baseline Heart rate less than 60 Baseline systolic Bp less than
- •Those with ECG abnormalities.
- •Patients with history of chest pain/palpitations/syncope, Patients with history of any visual disturbances, with Sick sinus syndrome.
- •Patients already on calcium channel blockers, azole antifungals, antiretroviral drugs and macrolide antibiotics, with hepatic impairment or renal dysfunction, pregnant and breastfeeding females and
- •Patients in whom intubation is thought to be difficult (time taken to intubate >.
结局指标
主要结局
To the best of literature . There is no study evaluating the hemodynamic attenuation of laryngoscope
时间窗: Laryngoscopic response till 5 minutes
and endotracheal intubation comparing oral ivabradine & oral clonidine & with the previous
时间窗: Laryngoscopic response till 5 minutes
studies & previous records .however studies have done between clonidine vs gabapentin & ivabradine alone.
时间窗: Laryngoscopic response till 5 minutes
次要结局
- 1.To the study the effect of these drugs on hemodynamic during intra operative & post operative(Period .)