NCT05850702尚未招募4 期
Attenuation of the Hemodynamic Response to Double-lumen Endotracheal Intubation With Nebulized Lidocaine: a Randomized, Double-blind, Controlled Trial
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 入组人数
- 92
- 主要终点
- mean arterial pressure after intubation
研究概览
简要总结
The goal of this clinical trial is to test the effect of nebulized lidocaine on the hemodynamic response in the participant undergoing double-lumen endotracheal intubation.
The main question it aims to answer is to evaluate the changes in mean arterial pressure after intubation.
Participants will inhale 5ml of 2% lidocaine by nebulization15min before intubation.
Researchers will compare saline group to see if saline effects
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aged 18-65 years, American Society of Anesthesiologists class I-II
- •participants undergoing double-lumen endotracheal intubation under general anesthesia
- •signed informed consent and volunteered to participate in the experiment
排除标准
- •Poor control of hypertension
- •preoperative arrhythmia
- •severe coronary artery or heart valve disease
- •sequelae of cerebrovascular accident
- •severe lung, liver, kidney and immune system diseases
- •Suspected difficult airway
- •confirmed or suspected allergy to this trial drug
- •As judged by the investigator to be ineligible for the study, such as communication impairment (language or intelligence)
研究组 & 干预措施
saline
Placebo Comparator
control group
干预措施: Saline (Drug)
lidocaine
Experimental
Intervention group
干预措施: Lidocaine (Drug)
结局指标
主要结局
mean arterial pressure after intubation
时间窗: Immediately after intubation
次要结局
未报告次要终点
研究者
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