Study on Efficacy and Safety of Human Albumin in Burn Shock Recovery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 364
- 主要终点
- the mortality of the patients
研究概览
简要总结
To explore the effects and safety of human albumin in burn shock recovery, and then provide a theoretical basis for its rational use.
详细描述
A retrospective case-control study was conducted. Patients who admitted to the burn ward and needed fluid resuscitation during the period of January 2011 to December 2018 in our unit were identified. Patients were divided into two groups according to the severity of burns, the patients with a 20%<TBSA≤50% constituted the moderate and severe burn group, the patients with a TBSA>50% constituted the severest burn group, and then the patients who used albumin for resuscitation constituted the albumin group, the patients who did not use albumin constituted the control group. The primary outcome was mortality, and the secondary outcomes included hospital stay, ventilator supporting, fluid use, and complications.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •TBSA≥ 20% （TBSA，the total burn area.）
- •Admitted to hospital within 24 hours after injury.
排除标准
- •STB ≥ 33 μ mol/L
- •Cr ≥ 171 μ
- •Urine output l< 500 ml / 24 h
- •Pregnant and lactating women
- •Severe combined injury
- •Glucocorticoids users
- •Immunosuppressants users
- •Patients survived less than 48 hours
研究组 & 干预措施
the albumin group
The albumin group, the patients who used albumin for resuscitation during their hospitalization in the burn ward constituted the albumin group.
干预措施: Albumin (Drug)
结局指标
主要结局
the mortality of the patients
时间窗: during the patients's hospitalization, an average of 1-2 month.
The mortality of the patients during their hospitalization.
次要结局
- the length of the patients's hospital stay(during the patients's hospitalization, an average of 1-2 month.)
- the number of patients that using ventilators(during the patients's hospitalization, an average of 1-2 month.)
- Volume of fluid used for resuscitationVolume of fluid used for resuscitation the volume of the patients's resuscitation fluid(during the patients's hospitalization, an average of 1-2 month.)
- the number of complications that the patients occurred(during the patients's hospitalization, an average of 1-2 month.)