The efficacy of intravenous immunoglobulin (IVIg) in patients with severe COVID-19 who have not responded to standard three-drug protocol

Phase 2

• Conditions: U07.1; COVID-19 disease.; COVID-19, virus identified

• Registration Number: IRCT20200325046859N1
• Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 18 May 2020

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Informed consent for inclusion in the study
Age range within 18 to 25 years old
Definitive diagnosis with COVID-19
Having one of the factors of decrease in consciousness level, RR=24? BP<90/60, Multi-lobe lung problem and hypoxemia
Certainty about non responsiveness of standard three-drug protocol of hydroxychloroquine / chloroquine + lupinavir / ritonavir + ribavirin

Exclusion Criteria

Sensitivity to IVIg
Having a comorbidities such as heart diseases that IVIg cannot be used

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Fever. Timepoint: before and after treatment. Method of measurement: Thermometer.;Respiration rate. Timepoint: before and after treatment. Method of measurement: counting the number of breaths patients take per minute.;Findings of chest CT scan. Timepoint: before and after treatment. Method of measurement: CT scan machine.;Pulse. Timepoint: before, during and after treatment. Method of measurement: patient monitoring device.;SpO2. Timepoint: before, during and after treatment. Method of measurement: patient monitoring device.;WBC. Timepoint: before and after treatment. Method of measurement: biochemical tests.;Number of lymphocytes. Timepoint: before and after treatment. Method of measurement: biochemical tests.;Lactate dehydrogenase. Timepoint: before and after treatment. Method of measurement: biochemical tests.;C-Reactive Protein (CRP). Timepoint: before and after treatment. Method of measurement: biochemical tests.