Differences in Frail and Non-frail Critically-ill Patients in Functional Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 731
- 试验地点
- 1
- 主要终点
- Probability not to deteriorate in functional status during the hospital stay
研究概览
简要总结
This is a prospective analysis of patient registry data of intensive care patients. The aim is to investigate if frailty is a predictor of decline of functional status of critically ill patients during their hospital stay.
详细描述
Elderly critical-ill patients with a high frailty level are becoming increasingly important in the ICU and the health system. Especially, questions about the course of the individual proceeding, withhold of therapy and level of care are controversial among caretakers, as outcome and functional independence remain still unclear in these patients.
This applies particularly in view of the fact that large studies such as VIP1 showed an inverse association of high frailty classes with short-term survival.
Our main objective in this study was to focus on functional outcome and independency measured by Barthel Index after ICU stay regarding frailty, the effect of critical care and severity and prognosis of the disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •intensive care stay > 48 hours
排除标准
- 未提供
结局指标
主要结局
Probability not to deteriorate in functional status during the hospital stay
时间窗: a median of 30 days
Analysis of the course of functional status measured by the Barthel Score sub-components transfer and ambulation during the hospital stay. The Scale ranges from 0 (no transfer) to 15 (transfer to chair and back) for transfer and from 0 (no ambulation) to 15 (coming into stand and walk 50m without supervision) for ambulation.
次要结局
- Change in Functional status before hospital admission to ICU discharge(a median of 20 days)
- Change in Functional status before hospital admission to hospital discharge(a median of 30 days)
- ICU length of stay(a median of 11 days)
- Hospital length of stay(a median of 30 days)
- Rate of discharge disposition to home(1 day)
- ICU mortality(a median of 11 days)
- Hospital mortality(a median of 22 days)
研究者
Stefan Schaller
Principal Investigator
Technical University of Munich