NCT05756049Enrolling By Invitation不适用
Procalcitonin Protocol Use to Guide Antibiotic Therapy Duration in the Intensive Care Unit
适应症
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 入组人数
- 208
- 试验地点
- 1
- 主要终点
- Total days of antibiotic therapy
研究概览
简要总结
To compare and contrast antibiotic use and its effects on patient outcomes before and after the implementation of a PCT protocol in the ICU at Methodist Richardson Medical Center (MRMC).
详细描述
Based on previous clinical trials, current literature supports the use of PCT levels in combination with clinical assessments to help determine optimal antibiotic therapy. On May 30, 2022, MRMC launched a PCT protocol in the ICU that allows clinical pharmacy specialists to order PCT levels in certain bacterial infections. In order to determine the effects of the protocol, a retrospective quasi-experimental review will be conducted
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •● Patients aged 18 years or older
- •Patients being monitored on the PCT protocol
- •ICU location status for at least part of the admission
- •Received antibiotics in the ICU for a diagnosis of:
- •Community-acquired pneumonia
- •Hospital-acquired pneumonia
- •Ventilator-associated pneumonia
- •Sepsis and/or septic shock
- •Uncomplicated bacteremia with known source
- •Chronic obstructive pulmonary disorder exacerbation
- •Asthma exacerbation
排除标准
- •Received antibiotics in the ICU for a diagnosis of:
- •Uncomplicated skin and soft tissue infections
- •Bacterial infections that require prolonged antibiotic therapy (e.g., osteomyelitis, endocarditis, tuberculosis, etc.)
- •Intra-abdominal infection
- •Urinary tract infection
- •Bacterial meningitis
- •Estimated Glomerular Filtration Rate <15 mL/min
- •Requiring renal replacement therapy
- •Status post cardiac arrest/target temperature management
结局指标
主要结局
Total days of antibiotic therapy
时间窗: 6 months
Actual antibiotic days and predicted antibiotic days (i.e., SAAR)
次要结局
未报告次要终点
研究者
研究点 (1)
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