Comparing two methods of estimating the severity of individual narrowings in heart arteries, when there is more than one narrowing

Not Applicable

• Conditions: Coronary artery disease (CAD) with serial stenoses; Circulatory System; Atherosclerotic heart disease

• Registration Number: ISRCTN18106869
• Lead Sponsor: Guy's and St Thomas' NHS Foundation Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-05-14
• Last Update Posted: 2 September 2024
• Study Completion: 2025-08-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 87

Inclusion Criteria

Current participant inclusion criteria as of 14/07/2021:
1. A focal lesion on angiography (at least 50% diameter stenosis) in a coronary artery
2. One of the following:
2.1. A second focal lesion (at least 50% diameter stenosis) which the operator would consider treating with separate (non-overlapping) stents
2.2. A segment of diffuse disease
3. Target vessel diameter of at least 2.5 mm, suitable for passing a pressure wire

Previous participant inclusion criteria:
1. A focal lesion on angiography (at least 50% diameter stenosis) in a coronary artery and either a second focal lesion (at least 50% diameter stenosis) or a segment of diffuse disease, which the operator would consider treating with separate (non-overlapping) stents
2. A vessel diameter of at least 2.5 mm, suitable for passing a pressure wire

Exclusion Criteria

1. ST-elevation myocardial infarction (STEMI)
2. Target vessel is considered the culprit for an Acute Coronary Syndrome (ACS) <72 hours before consent
3. Vessels protected by a graft with a history of previous coronary artery bypass grafting
4. Age <18 years
5. Unable to provide written informed consent (IC)
6. Known pregnancy or breastfeeding at time of randomisation

Study & Design

• Study Type: Interventional
• Study Design: Not specified