Multicenter study of the effect of loop diuretics for liver function and kidney function for patients using tolvapta
- Conditions
- Patient with cirrhotic ascites with concomitant loop diuretic who showed body weight loss of 1.5 kg or more at 1 week after tolvaptan administration
- Registration Number
- JPRN-UMIN000033223
- Lead Sponsor
- The third department of internal medicine, Nara Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 100
Not provided
1) Poor cardiac organ function a) Patients with congestive heart failure above NYHA class3 b) Patients with severe hypertension 2) Patients with severe and active infectious disease (exclude HBV,HCV hepatitis) 3) Patients with or had HIV 4) Patients taking dialysis 5) Patients with portal tumor thrombosis (Vp3 or Vp4) 6) Patients with hepatic encephalopathy 7) Patients with crucial digestive bleedings within 4 weeks 8) Patients had the following treatment a) Systemic chemotherapy within 4 weeks b) Being treated with invasive surgical therapy within 4 weeks 9) Patients with oral intake difficulty 10)Pregnant woman, lactating woman, or a woman suspected of pregnancy 11)Patients with severe allergic reaction to this study 12)Patients with drug abuse or psychological disorders 13) Patients concluded to be inappropriate to participate in this study by their physicians
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare the differences in liver function (Alb value) and renal function (BUN, Cr, eGFR, cystatin C), before and 12 month after administering furosemide or azosemide
- Secondary Outcome Measures
Name Time Method