Registry to collect clinical data on the effect and symptom control of electrochemotherapy for head and neck tumors

niversitätsklinikum Jena, Klinik für Hals-, Nasen- und Ohrenheilkunde0 个研究点目标入组 150 人开始时间: 2024年5月7日最近更新: 2024年8月19日

适应症

试验速览

暂无简介。

•? Histologically confirmed malignant neoplasm of any kind
•? Progressive and / or metastatic disease or
•? Primary disease that is not suitable for surgery due to the patient's general condition or the need for a very extensive surgical procedure or
•? Patient refuses standard treatments or provides written informed consent. Inclusion is possible if the patient refuses another form of standard treatment. Patient gives written consent for treatment with electrochemotherapy.
•? Measurable lesions that are suitable for the application of electrical impulses
•? Treatment-free interval of at least 4 weeks after previous chemotherapy or radiotherapy of the target lesions
•? Patients must be mentally capable of understanding the information and signing the consent form

•? Patients with symptomatic or rapidly progressive metastases outside the ENT area
•? Presence of lesions that are not indicated for treatment with ECT (bony infiltration, infiltration of large vessels, etc.)
•? Acute pneumonia
•? Pulmonary dysfunction
•? Unrecoverable severe coagulation disorders
•? Previous allergic reactions to bleomycin
•? Cumulative dose of 240,000 IU BLM/m² was previously exceeded
•? Chronic renal dysfunction (creatinine > 150 µmol/L)
•? Pregnancy or breastfeeding

发起方

niversitätsklinikum Jena, Klinik für Hals-, Nasen- und Ohrenheilkunde