The Effects of Two Different Ventilation Strategies on Lung Ventilation: An Ultrasonographic Evaluation.

Not Applicable

• Conditions: Prostate Cancer
• Interventions: Other: Pressure Controlled Ventilation; Other: Volume Controlled Ventilation

• Registration Number: NCT03740854
• Lead Sponsor: Istanbul University

Brief Summary

This study will be performed in robotic assisted laparoscopic radical prostatectomy patients in Cerrahpasa Medical Faculty Monoblock Operating Room. Since robot-assisted laparoscopic radical prostatectomy is a surgical procedure which requires long-term mechanical ventilation, excessive trendelenburg position (30-45 °) and pneumoperitoneum; these interventions may lead to respiratory complications such as ventilation difficulty and aeration loss in patients. Nowadays, lung ultrasonography has been used in anesthesia practice and intensive care units in order to determine lung aeration loss. In this study, the investigators aimed to compare the possible aeration loss in lung parenchyma during pressure controlled ventilation and volume controlled ventilation which are frequently used in anesthesia practice in patients undergoing robotic radical prostatectomy.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2018-11-12
• Study First Submitted QC: 2018-11-12
• Study First Posted: 2018-11-14
• Study Start: 2018-12-04
• Status Verified: 2019-02
• Last Update Submitted: 2019-02-26
• Last Update Posted: 2019-02-27
• Primary Completion: 2019-11-01
• Study Completion: 2020-07-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 72

Inclusion Criteria

18-75 age

• Patient who will be undergo robot assisted laparoscopic prostatectomy surgery
• Patient with ASA (American Society of Anesthesiologists) Score 1-3

Exclusion Criteria

• Patients with ASA Score above 3
• Patients with obstructive (FEV1<%60) or restrictive pulmonary disease (FVC<%60)
• Patients with intrathoracic operation history
• Heavy smokers (>25 cigarettes/day)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Pressure Controlled Ventilation	Pressure Controlled Ventilation	Patients undergoing pressure controlled ventilation
Volume Controlled Ventilation	Volume Controlled Ventilation	Patients undergoing volume controlled ventilation

Primary Outcome Measures

Name	Time	Method
The difference between LUS Scores at T5 in patients ventilated with VCV and PCV	(T5) 60 minutes after patients come to the recovery room.	Lung Ultrasonography will be applied to patients after surgery in the recovery room at T5. Two different groups' LUS scores will be calculated and compared.

Secondary Outcome Measures

Name	Time	Method
The difference between LUS Scores at T3 in patients ventilated with VCV and PCV	(T3) 5 minutes after the surgical procedure is finished	Lung Ultrasonography will be applied to patients at Trendelenburg position after the surgical prosedure is finished. Two different groups' LUS scores will be calculated and compared.
The difference between LUS Scores at T2 in patients ventilated with VCV and PCV	(T2) 5 minutes after intubation	Lung Ultrasonography will be applied to patients after intubation. Two different groups' LUS scores will be calculated and compared.
The difference between LUS Scores at T4 in patients ventilated with VCV and PCV	(T4) 5 minutes after taking the patient to supin position	Lung Ultrasonography will be applied to patients at supin position after the surgical prosedure is finished. Two different groups' LUS scores will be calculated and compared.

Trial Locations

Locations (1)

Medical Faculty of Cerrahpasa; 🇹🇷 Istanbul, Turkey