Hemodynamic Effects of Ventilation Modes
- Conditions
- Respiration, ArtificialLaparoscopyHemodynamics
- Interventions
- Procedure: Mode of Mechanical Ventilation
- Registration Number
- NCT03684291
- Lead Sponsor
- Ufuk University
- Brief Summary
Different ventilation modes can be used in laparoscopic surgeries. These surgeries are performed in steep Trendelenburg position with serious hemodynamic disturbances. This study aims to observe the hemodynamic effects of two different ventilation modes in laparoscopic gynecologic surgery performed in steep Trendelenburg position.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 30
Inclusion Criteria
- Women of ASA I and II classification between 18-65 years scheduled for elective gynecologic laparoscopic surgery
Exclusion Criteria
- Patient refusal to participate
- Patients with severe cardiac (congestive heart failure etc) and pulmonary (COPD, pulmonary hypertension) disease (ASA > III)
- Morbid obesity
- Negative Allen test
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Group V Mode of Mechanical Ventilation The patients in this group are ventilated using VCV (Volume Control Ventilation) mode (FiO2 50%, Tidal volume: 6-8 ml/kg (ideal body weight), frequency: 12/minute, I/E ratio: 1/2, PEEP not applied) Group P Mode of Mechanical Ventilation The patients in this group are ventilated using PCV-VG (Volume Guaranteed Pressure Control Ventilation) mode (FiO2 50%, Tidal volume: 6-8 ml/kg (ideal body weight), frequency: 12/minute (EtCO2 kept between 35-40 mmHg), Pressure limit: 30 cm H2O, I/E:1/2, PEEP not applied)
- Primary Outcome Measures
Name Time Method Measurement of changes in MAP T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation Mean arterial pressure (MAP) (mmHg)
Measurement of changes in heart rate T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation Heart rate (bpm)
Measurement of changes in systemic vascular resistance index T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation Systemic vascular resistance index (dyne x sec/cm2)
Measurement of changes in stroke volume index T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation Stroke volume index (mL/m2)
Measurement of changes in cardiac index T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation Cardiac index L(min x m2)
Measurement of changes in stroke volume variation T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation Stroke volume variation (%)
Measurement of changes in cardiac cycle efficiency T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation Cardiac cycle efficiency (units)
Measurement of changes in aortic dp/dt T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation Aortic dP/dt (mmHg/msec)
- Secondary Outcome Measures
Name Time Method Measurement of changes in peak airway pressure T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation Ppeak (Peak airway pressure)
Measurement of changes in mean airway pressure T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation Pmean (Mean Airway Pressure),
Measurement of changes in plateau airway pressure T0: Induction (Baseline) T1: Change after 30 minutes pneumoperitoneum T2: Change after desufflation Pplateau (Plateau Airway Pressure)
Trial Locations
- Locations (1)
Ufuk University Faculty of Medicine
🇹🇷Ankara, Balgat, Turkey