Multi Center Case Control Study on Multiple Risk Factors of Aplastic Anemia

Completed

• Conditions: Aplastic Anemia
• Interventions: Other: AA or not

• Registration Number: NCT03208647
• Lead Sponsor: Shengyun Lin

Brief Summary

To ascertain the risk factors of AA in ZheJiang Province of China at the moment, especially the comprehensive multiple factors risks. The author conducted a case-control research included 338 AA cases and 1464 controls. Subjects were surveyed using same standard questionnaire including personal data, past histories of diseases, family history and histories of occupational and daily exposure to harmful substances. Single and multiple Logistic regression analyses were made using SPSS17.0 on the dates to study potential factors in the development of AA.

Detailed Description

Not available

Study Timeline

• Study Start: 2003-01-01
• Primary Completion: 2014-01-01
• Study Completion: 2014-01-01
• Study First Submitted: 2016-07-18
• Status Verified: 2017-07
• Study First Submitted QC: 2017-07-03
• Last Update Submitted: 2017-07-03
• Study First Posted: 2017-07-05
• Last Update Posted: 2017-07-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1802

Inclusion Criteria

• All the patients of AA group met a AA diagnostic criteria；The control group were chosen from other departments who were under acute infection (such as pneumonia), acute abdominal emergency (such as appendicitis), cataract surgery;
• 1-65 years old, male or female;
• Sign the informed consent.

Exclusion Criteria

• With myelodysplastic syndrome, leukaemia, multiple myeloma,megaloblastic anaemia, paroxysmal sleep hemoglobinuria disease blood disease, etc.
• History of tumor, radiation or chemotherapy, once accept the immunological therapy, autoimmune diseases or allergic disease patients;
• Patients with neurological diseases.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
AA Group	AA or not	All the patients of AA group met a AA diagnostic criteria；

Primary Outcome Measures

Name	Time	Method
the items about daily Exposures	January 2014	Whether living or working near chemical factory or ionizing radiation, whether living in newly decorated apartments/house, having pets/livestock

Secondary Outcome Measures

Name	Time	Method
Individual Behaviours	January 2014	Smoking (daily number of cigarettes )
Occupational Exposures	January 2014	the duration of exposure to harmful substance(including industrial glue）
Individual Health Status	January 2014	the time for the first onset of AA
Family disease history	January 2014	Whether having the same disease, other blood diseases, malignant tumor