The Efficacy of Platelets Rich Plasma for Ovarian Rejuvenation

Not Applicable

Completed

• Conditions: Infertility, Female
• Interventions: Other: Autologous PRP preparation

• Registration Number: NCT03946813
• Lead Sponsor: Al-Kindy College of Medicine

Brief Summary

In recent years, an increased approach has appeared in the use of autologous blood products to assist tissue and organ healing. Application of platelet rich plasma (PRP) has emerged as a potential solution for infertile women with poor ovarian reserve in reproductive specialty.

Detailed Description

Quantitative and qualitative functional improvement of ovarian function has been reported in several studies after using autologous PRP in a reproductive field. Ovarian rejuvenation, stimulating the ovaries to produce new eggs after injecting PRP, can offer hope for renewed fertility to women with poor reserve volume, advanced maternal age, or either naturally occurring or premature menopause. But, these encouraging results should be supported by several new studies.

This study aimed to estimate the efficacy of trans-vaginal ovarian injection with PRP in rejuvenates ovaries in woman with poor ovarian reserve, and to assess any association of some women variables (age, menstrual status, parity, BMI) as predicting factors in success of ovarian injection with PRP.

Study Timeline

• Study Start: 2018-08-20
• Study First Submitted: 2019-05-06
• Study First Submitted QC: 2019-05-09
• Study First Posted: 2019-05-13
• Primary Completion: 2019-05-31
• Study Completion: 2019-05-31
• Status Verified: 2019-10
• Last Update Submitted: 2023-05-03
• Last Update Posted: 2023-05-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

1. Menopause or peri-menopause under the age of 50.
2. Premature ovarian insufficiency which is ovarian failure before the age of 40.
3. Woman with primary ovarian failure of any cause.

Exclusion Criteria

1. A previous injection with any medication, plasma, or PRP
2. Invisible or difficult access ovaries.
3. Medical disease or unfit for anesthesia patient.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Poor ovarian reserve	Autologous PRP preparation	Infertile women with poor ovarian reserve

Primary Outcome Measures

Name	Time	Method
Anti-Müllerian hormone (AMH) concentration	4 weeks	Before after intervention measurement
Follicle-stimulating hormone (FSH) concentration	4 weeks	Before after intervention measurement
Antral follicles numbers	4 weeks	Before after intervention measurement

Trial Locations

Locations (1)

High Institute for Infertility Diagnosis and Assisted Reproductive Technologies; 🇮🇶 Baghdad, Iraq