Lactated Ringer's and PlasmaLyte in Critically Ill Adults

• Conditions: Critical Illness
• Interventions: Drug: RL; Drug: PLA

• Registration Number: NCT03813563
• Lead Sponsor: West China Hospital

Brief Summary

In recent years, there has been a large amount of literature reports that normal saline can increase the incidence of renal injury in critically ill patients compared with balanced salt solution.However, no studies have compared the effects of different types of balanced salt solutions on the incidence of renal injury.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-13
• Primary Completion: 2018-12-15
• Status Verified: 2019-01
• Study First Submitted: 2019-01-19
• Study First Submitted QC: 2019-01-19
• Last Update Submitted: 2019-01-22
• Study First Posted: 2019-01-23
• Last Update Posted: 2019-01-24
• Study Completion: 2019-02

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 12000

Inclusion Criteria

• All patients admitted to ICU

Exclusion Criteria

• Patients <18 year old when admission
• Patients who stay less than 24 hours in ICU
• Patients who do not sufficient data for further analysis
• Readmission patients during the study period

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Mix group	PLA	Patients who used two balanced salt solutions during icu stay
RL group	RL	Patients who have only used lactated Ringer's during icu stay
PLA group	PLA	Patients who have only used PlasmaLyte during icu stay
Mix group	RL	Patients who used two balanced salt solutions during icu stay

Primary Outcome Measures

Name	Time	Method
The incidence of acute kidney injury	from admission to 28 days	The incidence of acute kidney injury

Secondary Outcome Measures

Name	Time	Method
the incidency of CRRT events	from admission to 28 days	the incidency of CRRT events
the ventilation free days	from admission to 28 days	the ventilation free days
the vasopressure free days	from admission to 28 days	the vasopressure free days

Trial Locations

Locations (1)

Department of Critical care medicine of West China Hospital; 🇨🇳 Chengdu, Sichuan, China