World Health Organization (WHO) , COVID19 Case Series of Post Covid 19 Rhino Orbito Cerebral Mucormycosis in Egypt

Phase 1

Completed

• Conditions: Mucormycosis; Rhinocerebral (Etiology); COVID-19
• Interventions: Procedure: debridment

• Registration Number: NCT06267326
• Lead Sponsor: Nasser Institute For Research and Treatment

Brief Summary

Objectives: identify and recognize clinical Characteristics, Pathophysiology, and management of a group of patients with rhino Rhino-Orbito-Cerebral Mucormycosis infection associated with Covid 19 viral infection

Detailed Description

Not available

Study Timeline

• Study Start: 2021-05-23
• Primary Completion: 2022-06-12
• Study Completion: 2023-08-21
• Study First Submitted: 2024-01-20
• Status Verified: 2024-02
• Study First Submitted QC: 2024-02-16
• Last Update Submitted: 2024-02-16
• Study First Posted: 2024-02-20
• Last Update Posted: 2024-02-20

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• all patients with mucormycosis post covid 19

Exclusion Criteria

• The patient not suffered from covid 19

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Twenty-one (60%) males and fourteen (40%) females, mean age was 44.17	debridment	Twenty-one (60%) males and fourteen (40%) females, mean age was 44.17 years eighteen patients presented with COVID 19 and seventeen patients presented to our hospital post healing with history of using large doses of systemic corticosteroids. patients were managed by aggressive surgical debridement, antifungal drugs Amphotericin B and adjunctive treatment like local irrigation with amphotericin B and hyperbaric oxygen according to systemic conditions of patients. Hyperbaric oxygen was used in five patients post-surgically. all investigations were done with mean values of blood glucose level, hemoglobin and WBC were noticeably abnormal. The degree of severity, length of stay, and mortality rate were significantly correlated with the severity of systemic predisposing factors
Twenty-one (60%) males and fourteen (40%) females, mean age was 44.17 years	debridment	Twenty-one (60%) males and fourteen (40%) females, mean age was 44.17 years eighteen patients presented with COVID 19 and seventeen patients presented to our hospital post healing with history of using large doses of systemic corticosteroids. patients were managed by aggressive surgical debridement, antifungal drugs Amphotericin B and adjunctive treatment like local irrigation with amphotericin B and hyperbaric oxygen according to systemic conditions of patients. Hyperbaric oxygen was used in five patients post-surgically. all investigations were done with mean values of blood glucose level, hemoglobin and WBC were noticeably abnormal. The degree of severity, length of stay, and mortality rate were significantly correlated with the severity of systemic predisposing factors

Primary Outcome Measures

Name	Time	Method
pain	two years	Visual Analog Score for pain
35 patients suffering from mucormycosis infection post covid 19	2 years	Ratio Scale. Visual Analog Score for pain Ratio Scale. Ratio Scale. ratio scale
25 patients were cured with comorbidity and 10 pateints died	2 years	ordinal scale Visual Analog Score for pain

Secondary Outcome Measures

Name	Time	Method
Visual Analog Score for pain	2years	pain

Trial Locations

Locations (1)

Omar Elmonofy; 🇪🇬 Cairo, Egypt