Effects of Strength Exercise on Fall Risk in Elderly With Alzheimer's Disease

Not Applicable

Completed

• Conditions: Fall Risk; Alzheimer Disease; Dementia; Alzheimer's Type (Etiology); Elderly; Resistance Training
• Interventions: Procedure: Strength exercise; Other: Usual treatment

• Registration Number: NCT04981587
• Lead Sponsor: University of Jaén

Brief Summary

Interventional study to show the effects of strength exercise on fall risk in elderly with Alzheimer's disease

Detailed Description

Not available

Study Timeline

• Study Start: 2021-05-01
• Study First Submitted: 2021-07-19
• Study First Submitted QC: 2021-07-28
• Study First Posted: 2021-07-29
• Primary Completion: 2021-12-10
• Status Verified: 2022-03
• Study Completion: 2022-03-04
• Last Update Submitted: 2022-03-04
• Last Update Posted: 2022-03-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 64

Inclusion Criteria

• accept to participate in the study, through informed consent
• subjects aged 60 or over with medical diagnosis of Azlheimer´s disease
• minimal physical and mental state to perform the cognitive tests and strength exercise routine

Exclusion Criteria

• Neurodegenerative disease other than Alzheimer's disease
• Suffering from serious somatic or psychiatric illnesses
• Patients who have practiced strength exercise regularly

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intervention group	Strength exercise	This is the group that receives strength exercise in addition to usual treatment
Intervention group	Usual treatment	This is the group that receives strength exercise in addition to usual treatment
Control group	Usual treatment	This is the group that only receives usual treatment

Primary Outcome Measures

Name	Time	Method
Change from baseline Short physical performance battery (SPPB) at 3 and 6 months	Baseline, 3 and 6 months (3 months after intervention)	Informs about fall risk and mobility Score: 0-12 High score means better result

Secondary Outcome Measures

Name	Time	Method
Change from baseline Mini Mental State Examination (MMSE) at 3 and 6 months	Baseline, 3 and 6 months (3 months after intervention)	This test gives us information about the cognitive performance of the participants Score: 0-30 High score means better result
Change from baseline FRAIL test at 3 and 6 months	Baseline, 3 and 6 months (3 months after intervention)	This rapid test allows to determine the state of frailty of older people Score: 0-5 High score means worst result
Change from baseline One Maximum repetition strength test (1 MR) at 1,2,3 and 6 months	Baseline, 1 , 2 , 3 and 6 months (3 months after intervention)	Allows you easily to assess maximum strength Score: 0-∞ High score means more strength level
Change from baseline Lawton Instrumental Activities of Daily Living Scale (IADL) at 3 and 6 months	Baseline, 3 and 6 months (3 months after intervention)	This tool gives us information about performance in activities of daily living Score: 0-8 High score means better result
Change from baseline Quality of life Alzheimer Disease (QoL-AD) at 3 and 6 months	Baseline, 3 and 6 months (3 months after intervention)	Through this test we can know the level of quality of life of users who suffer from this disease Score: 0-52 High score means better result
Change from baseline Neuropsychiatric Inventory (NPI-Q) at 3 and 6 months	Baseline, 3 and 6 months (3 months after intervention)	This tool allows to specify the neuropsychiatric symptoms patients present Score: 0-36 High score means worst result
Change from baseline Activities specific balance confidence scale (ABC scale) at 3 and 6 months	Baseline, 3 and 6 months (3 months after intervention)	This questionnaire allows to measure the balance of a person Score: 0-100% High percentage means better result
Change from baseline Manual dynamometry at 1,2,3 and 6 months	Baseline, 1, 2, 3 and 6 months (3 months after intervention)	This test allows to quantify force an individual presents in a simple way Score: 0-∞ High score means better result
Modified Borg scale	3 times/week during strength exercises sessions	In this way we can measure the level of perceived exertion during the intervention with strength exercise Score: 0-10 High score means more fatigue

Trial Locations

Locations (2)

Alexander achalandabaso; 🇪🇸 Alcalá De Henares, Madrid, Spain

A.F.A La Estrella; 🇪🇸 Jaén, Andalucía, Spain