Acupuncture treatment of sensorineural hearing loss with MCI clinical efficacy and related mechanisms

Not Applicable

Conditions: sensorineural hearing loss

Registration Number: ITMCTR2100005203

Lead Sponsor: Hospital of Chengdu University of Traditional Chinese Medicine

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: All

Target Recruitment: Not specified

Inclusion Criteria

(1) Aged over 18 years old;
(2) In line with the diagnosis of sensorineural hearing loss, that is, there are at least two frequencies at the 0.5khz, 1khz, 2khz, and 4khz levels where the binaural air conduction hearing threshold difference is greater than 20dB, and the air-bone conduction difference is less than 5db
(3) Diagnosis consistent with MCI at the same time: (a) The patient or the insider reported, or the experienced clinician found cognitive impairment; (b) There was objective evidence of one or more cognitive impairment (from cognitive impairment test); (c) Complex instrumental daily abilities can be slightly impaired, but maintain independent daily living abilities; (d) The diagnosis of dementia has not yet been reached;
(4) Patients should be included under the condition of signing the informed consent form.

Exclusion Criteria

(1) Patients with new cardiovascular and cerebrovascular diseases and hearing loss again in the past three months;
(2) People with a history of large-scale cerebral infarction, patients with severe endocrine system diseases, patients with severe infectious diseases, and patients with toxic encephalopathy;
(3) The patient has fainted needles, and the treatment site has skin breakage, infection and other contraindications that are not suitable for acupuncture treatment;
(4) The patient is conscious or mentally disabled and cannot cooperate to complete the study;
(5) Women with acute abdomen, pregnancy and lactation;
(6) There is a history of head and neck trauma, and a history of taking special drugs;
(7) In the past three months, the patient has accepted or is participating in other clinical trials;
(8) Patients have contraindications to MRI scans, such as claustrophobia, tattoos, or implantation of ferromagnetic metals.