A double-blind randomised clinical trial to assess the effectiveness of a potassium-enriched salt substitute toimprove sodium-to-potassium ratio and reduce blood pressure in adolescents and their families in Soweto,South Africa

MRC Wits Developmental Pathways for Health Research Unit0 个研究点目标入组 1,500 人开始时间: 2023年6月9日最近更新: 2024年3月4日

适应症

试验速览

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•1. Male/Female.
•2. African descent living in Soweto.
•3. Adolescents, aged 13-19 years, primary caregiver (parent/guardian) and where the primary caregiver is <40 years of age, also a member of the household (aged 40-70 years).
•4. Eats in the home a minimum of five days a week.
•5. Stays in the home a minimum of five days a week.
•6. Individuals presenting with new clinical hypertension (will be referred).
•7. Use of ACE inhibitors or Angiotensin receptor blockers (participant will be flagged for monitoring.

•1. Inability to read or understand English.
•2. Self-reported previous diagnosis of kidney disease/diminished kidney function (any household member regardless of participation).
•3. Urine dipstick indicating potential kidney disease/diminished kidney function as indicated by proteinurea (any household member regardless of participation).
•4. Estimated Glomerular Filtration Rate below 60 mL/min (any household member over 20 years of age regardless of participation).
•5. Use of Potassium-sparing diuretics (any household member regardless of participation).
•6. Potential contraindication to the potassium-enriched salt (any household member regardless of participation).
•7. Considered to eat most meals outside of the home.
•8. Previous diagnosis or currently self-reporting any eating disorder.
•9. Participating in any other trial.
•10. Households without cooking facilities.
•11. High-level athletes.
•12. Self-reported pregnancy at time of screening (any household member regardless of participation).

发起方

MRC Wits Developmental Pathways for Health Research Unit