A double-blinded randomised clinical trial to evaluate the effects of muscle strength training, or muscle endurance training compared with sham exercise training in the treatment of osteoarthritic-related pain.

niversity of Sydney0 个研究点目标入组 75 人开始时间: 2005年8月26日最近更新: 2020年1月13日

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•Primary (idiopathic) osteoarthritis of hip &/or knee identified using standard criteria of the American College of Rheumatology for classification of clinical osteoarthritis (pain of the knee or hip on most days of the past month, morning stiffness by history; crepitus, bony enlargement of the knee, pain or limitation of motion on internal rotation of the hip on exam, or radiographic evidence of osteophytes or joint space narrowing from medical record review). pain of at least mild intensity (>25 on a 100mm visual analog scale). Community-dwelling (living independently) ambulatory without human assistance. Willingness to be randomised to experimental or control groupsAbility to attend scheduled exercise and testing sessions.

•Regular exercise of any kind over the past 6 months (1dpw). Secondary osteoarthritis (traumatic or post-surgical), rheumatic disease, gouty or septic arthritis, Paget's disease, pseudogout, major congenital abnormalities, hemachromatosis, Wilson's disease and other rare forms of arthritis Joint injury, injection or surgery within the past 6 months or joint replacement. Acute or terminal illness. Unstable systemic disease precluding exercise such asAcute myocardial infarction in the past 6 months. Unstable cardiovascular disease (angina, cardiac arrhythmias, hypertension). Uncontrolled diabetes or other metabolic disease.Disorders of the nervous system disrupting voluntary movement (cerebrovascular accident/stroke with residual paresis, Parkinson's disease, demyelination disorders - multiple sclerosis). Severe functional limitation (unable to walk unaided). Musculoskeletal disease/injury severely restricting voluntary movement. (severe arthritis/ankylosis, pain related to osteoporotic vertebral crush fractures, rotator cuff disease/injury). Cognitive impairment Other contra-indication to exercise as assessed during the screening history and physical examination by a study physician.

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