The Impact of Regular Usage of Paracetamol at Therapeutic Doses on Bronchial-Hyper-responsiveness and Lung Functions in the Asthmatic Subjects

Phase 4

Completed

• Registration Number: CTRI/2009/091/000490
• Lead Sponsor: il

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 24 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

?Mild- to-moderate asthmatics in accordance with the GINA guidelines
? Male and females18?70 years old
?Baseline FEV1 ≥60% predicted
?PC20 methacholine of ≤8.0 mg/ml

Exclusion Criteria

?Subjects with aspirin induced asthma
?Asthmatics with exacerbation of asthma within the previous three months requiring oral steroids, nebulised bronchodilator, antibiotics or an emergency visit to the doctor
?Current or past cigarette smoking >10 pack years
?History of allergy or sensitivity to paracetamol, aspirin or ibuprofen
?Current or past history of liver disease or on potentially hepatotoxic drugs
?Deranged liver function, signified by elevated enzyme levels
?Current regular use of paracetamol
?History of alcoholism, or current excessive alcohol intake
?Previous intentional acute overdose of paracetamol, previous suicide attempt or current depression
?Evidence of malnutrition or BMI <20 kg/m2
?Women of child-bearing age not using adequate contraception

Study & Design

• Study Type: Interventional
• Study Design: Not specified