NCT01216540已完成不适用
Occurrence and Economic Impact of Nephrotoxicity Associated With Vancomycin Exposure
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 398
- 试验地点
- 1
- 主要终点
- Time to nephrotoxicity
研究概览
简要总结
The primary goal of this study is to determine if there is an association between greater exposure to vancomycin and the development of nephrotoxicity. The secondary goal is to estimate the costs to the hospital associated with these nephrotoxic events.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years or older at time of hospital admission
- •Had an absolute neutrophil count of ≥ 1000 cells/mm^3
- •Received > 48 hours of intravenous vancomycin therapy
- •Had one or more vancomycin trough levels reported within the 96 hours after therapy initiation
- •Had a baseline serum creatinine level of < 2.0 mg/dL and baseline creatinine clearance level of ≥ 30 mL/min
排除标准
- •Previous diagnosis of cystic fibrosis
结局指标
主要结局
Time to nephrotoxicity
时间窗: within 72 hours post completion of vancomycin therapy
次要结局
- Hospital costs(until discharge)
- Length of stay(until discharge)
研究者
Vanessa Stevens
Principal Investigator
University at Buffalo
研究点 (1)
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