Determining the gut bacteria in the setting of high blood pressure

Not Applicable

Completed

• Conditions: hypertension; gut microbiota; Cardiovascular - Hypertension

• Registration Number: ACTRN12620000958987
• Lead Sponsor: Dr Francine Marques

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2018-04-05
• Study Start: 2020-09-25
• Last Update Posted: 5 October 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

For normotensive participants:
•Diagnosis of normal blood pressure: Systolic blood pressure <140 mmHg and diastolic blood pressure <90 mmHg
•Age: 40-70 years old
•Gender: either
•Body mass index: 18.5-30

For hypertensive participants:
•Diagnosis of hypertension: Systolic blood pressure >140 mmHg and diastolic blood pressure >90 mmHg
•Age: 40-70 years old
•Gender: either
•Body mass index: 18.5-30

Exclusion Criteria

Type 1 or type 2 diabetes, chronic kidney disease, gastrointestinal diseases (including history of intestinal surgery, inflammatory bowel disease, celiac disease, lactose intolerance, chronic pancreatitis or other malabsorption disorder), use of probiotics or antibiotics in the past 3 months, and taking medication for hypertension.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in the gut microbiota (taxa and diversity by next-generation sequencing) [24 hours after the study visit]

Secondary Outcome Measures

Name	Time	Method
Gut metabolites (short-chain fatty acids in plasma and fecal samples, by gas chromatography) [Once, from plasma collected during study visit]