The effects of plant sterols and stanol on cytokine production by mononucleair blood cells isolated out of blood from asthma patients

Completed

• Conditions: astma; asthma; 10006436

• Registration Number: NL-OMON33551
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

- 18 to 70 years of age
- Men or women
- asthma patient or healthy volunteer

Exclusion Criteria

- Current asthmatic exacerbations
- Other inflammatory based pathology like IBD, COPD, rheumatoid arthritis or HIV
- Autoimmune diseases like MS or Lupus
- Other conditions known to relate to Th1/Th2 balance disturbances like type II diabetes
- Any known (food) allergies
- Allergic asthma
- Retroviral infections with HTLV in the past
- Smoking
- Abuse of drugs and/or self-reported alcohol consumption of >2 drinks daily
- Pregnant or breast-feeding women
- Use of an investigational product containing plant sterols or stanols (benecol, becel pro-active or danacol) within the previous 30 days
- Having donated blood (as blood donor) within 1 month prior to the study or planning to do so during the study

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- differences in cytokine produktion by isolated PBMCs from asthma patients<br /><br>versus healthy controls<br /><br>- differences in cytokine produktion by exposing isolated PBMCs from asthma<br /><br>patients versus healthy controls to<br /><br>plant sterols and stanols</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>N.A. </p><br>