Insulin Sensitivity and Metabolism Before and After Treatment in Patients With Hypothyroidism
- Registration Number
- NCT00770016
- Lead Sponsor
- University of Aarhus
- Brief Summary
The aim of this study is to further characterize the treatment related changes in insulin sensitivity, substrate metabolism and intra hepatic- and intramyocellular lipid content in patients with hypothyroidism
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- written informed consent
- must be of legal age and competent
- Age > 18 years
- presently diagnosed with hypothyroidism
Exclusion Criteria
- alcohol consumption >21 units per week
- Malignant disease
- pregnancy
- magnetic implants or material in the body
- BMI > 30
- Heart disease (NYHA >2)
- Uncontrolled hypertension
- Manifest diabetes mellitus
- Changes in medication, with any influence on glucose metabolism, 2 months prior to and until the end of the trial.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description 1 Levothyroxin the aim of the present study is to characterize the treatment related changes in insulin sensitivity, substrate metabolism and intrahepatic - intramyocellular lipids in 12 adult patients, recently diagnosed with hypothyroidism
- Primary Outcome Measures
Name Time Method intracellular lipid content in liver and muscle before and after 3 months treatment with growth hormone intraabdominal lipid content before and after treatment insulin sensitivity before and after treatment intracellular signaling in the basal state and during insulin stimulation before and after treatment substrate metabolism before and after treatment
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Medical department M (Endocrinology and Diabetes), Aarhus University Hospital, Aarhus Sygehus,
🇩🇰Aarhus, Denmark