ISRCTN05758301CompletedNot Applicable
Metabolic substrate support in left ventricular hypertrophy -HINGE Trial ( Hypertrophy, Insulin, Glucose and Electrolytes Trial)
Record Provided by the NHSTCT Register - 2005 Update - Department of Health (UK)0 sites0 target enrollmentStarted: September 30, 2005Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Interventional
Eligibility Criteria
- Sex
- All
Inclusion Criteria
- •Patients eligible for entry into the trial will be consulted and recruited in:
- •1. Pre-surgical consultation clinic
- •2. Pre-admission clinic
- •3. During hospital admission for surgery
- •Before surgery they will have an echocardiogram/MRI scan to assess left ventricular hypertrophy. 2D directed M-mode echocardiography will be used to determine LV mass using the anatomically-validated cube formula. Consistency will be cross-checked using LV mass quantification from the area-length 2D method. There is no risk associated with transthoracic echocardiography. A subset of subjects will also undergo LV mass assessment using MRS. LV mass will be calculated using serial contiguous short axis TrueFISP cine sequences with 7mm slice thickness and 3mm gap using a 1. 5-Tesla magnet. Analysis will be performed off-line using Siemens ARGOS software. There is no biological risk to MR scanning, although patients with ferromagnetic material within the body have to be excluded (the most common example is that of older cerebral aneurysm clips).
Exclusion Criteria
- •Patients with ferromagnetic material within the body.
Investigators
Similar Trials
Completed
Not Applicable
Right Ventricular Metabolism in Pulmonary Arterial HypertensionHealthyPulmonary Arterial HypertensionNCT02763735Vanderbilt University Medical Center34
Completed
Not Applicable
Rt Ventricular Substrate Metabolism as a Predictor of Rt Heart Failure in Patients With Pulmonary Arterial HypertensionPulmonary Arterial HypertensionNCT01572077Ottawa Heart Institute Research Corporation20
Completed
Phase 2
PET Scan to Determine Areas of Blood Flow and Activity in the Hearts of Patients With Heart Disease Taking Beta-BlockersHeart Failure, CongestiveNCT00001402National Heart, Lung, and Blood Institute (NHLBI)130
Recruiting
Not Applicable
Magnetic Resonance Spectroscopy Studies of Cardiac Muscle MetabolismHeart Failure, CongestiveNCT00181259Johns Hopkins University500
Active, not recruiting
Phase 1
Evaluation of the role of regional pulmonary hypoperfusion in the development of vintilation induced lung injurySevere Acute Respiratory Distress Syndrome (ARDS)MedDRA version: 20.0 Level: LLT Classification code 10038651 Term: Respiration failure System Organ Class: 10038738 - Respiratory, thoracic and mediastinal disordersMedDRA version: 20.0 Level: PT Classification code 10001053 Term: Acute respiratory failure System Organ Class: 10038738 - Respiratory, thoracic and mediastinal disordersMedDRA version: 20.0 Level: SOC Classification code 10038738 Term: Respiratory, thoracic and mediastinal disorders System Organ Class: 10038738 - Respiratory, thoracic and mediastinal disordersEUCTR2018-001294-25-ITFONDAZIONE IRCCS CA' GRANDA OSPEDALE MAGGIORE POLICLINICO10