A comparative study of Majoon Najah and Sharbat Ahmad Shahi in Depression-A randomized open label double arm clinical trial.

The study is Randomized, parallel group, open label,comparative clinical trial to evaluate the efficacy and safety of Majoon Najahand Sharbat Ahmed Shahi in the management of Depression. Depression is a commonillness characterized by persistent sadness and a loss of interest inactivities that one normally enjoys, accompanied by an inability to carry outdaily activities, for at least two weeks. It is a serious mental health concernthat impacts a person’s ability to work, their relationships, and significantlydestroys their quality of life. It is believed that severe depression can havedevastating consequences including suicidal ideation and attempts. About 3.8percent of the population suffers from depression, including 5 percent ofadults. Approximately 280 million people in the world have depression. Womenare 50 percent more likely to experience depression when compared to men with aprevalence rate of 6 percent among women and 4 percent in men. The NationalMental Health Survey 2015 in India reports that 1 in 20 individuals aged 18 orolder have suffered from depression at least once in their lifetime. More than700 000 people die by suicide every year. The World Health Organizationestimates that depression accounts for 4.3 percent of the global disease burdenand projects that it will become the leading contributor by 2030. In modernmedicine, first-line course of antidepressant treatment is insufficient toachieve remission in 68 percent of cases. The current antidepressants used havelimitations in both efficacy and tolerability. The scientists are increasinglyfocusing on exploring and developing new antidepressant drugs derived fromplants and their active compounds. Unani medicine is known for being safe,effective, readily accessible, cost effective and with least side effects.Certain plants have been utilized in the Unani system of medicine for treatingpsychiatric ailments including depression. The purpose of the study is toevaluate the efficacy and safety of Majoon Najah and Sharbat Ahmed Shahi in themanagement of Depression on modern scientific parameters.