Intra-operative detection and localisation of high frequency oscillations in the ECoG to guide epilepsy surgery

Completed

• Conditions: hersenen, focale epilepsie; refractory focal epilepsy; intractable epilepsy

• Registration Number: NL-OMON45156
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 78

Inclusion Criteria

Patients of all ages with:
- Focal epilepsy that are planned for neurosurgery with aECoG, with the goal of tailoring the resection.
-Command of Dutch language of the patient/parents/legal representatives and capability of completing the questionnaires (by email or phone).

Exclusion Criteria

- Patients who underwent chronic ECoG monitoring preceding epilepsy surgery.
- Patients with an occipital focus undergoing aECoG.
- Patients with tailored tumor surgery with expected progressive course of disease (e.g. expected tumor growth, planned radiotherapy after surgery).*

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Outcome after epilepsy surgery after 1 year of follow-up dichotomized in total<br /><br>seizure freedom (Engel classification Ia&b) vs. seizure recurrence (Engel<br /><br>classification Ic-IV).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secundary study parameters are pre- vs post opertive differences in volume of<br /><br>brain tissue removed, neurological deficits, cognitive functioning, duration of<br /><br>surgery and aECoG recording and health related quality of life (QoL). </p><br>