Early Identification and Predictive Parsing for High Risk Group of Schizophrenia

Completed

• Conditions: High Risk Group of Schizophrenia

• Registration Number: NCT05042739
• Lead Sponsor: Wuhan Mental Health Centre

Brief Summary

An accurate identification of individuals at ultra-high risk (UHR) based on psychometric tools to prospectively identify psychosis as early as possible is required for indicated preventive intervention. The diagnostic comparability of several psychometric tools is unknown. To address the psychometric comparability of the CAARMS, SIPS and BSABS for subjects who are the immediate family and three-generation blood kinship of patients with schizophrenia. To verify the viability and reliability of the three instruments for these subjects. subjects who all are immediate family and three-generation blood kinship of patients with schizophreniawere interviewed. All the subjects were assessed for a UHR state by three psychometric tools including CAARMS, SIPS and BSABS. The psychometric diagnosis results including at risk of psychosis (UHR+), not at risk of psychosis (UHR-), and Psychosis. Demographic and clinical characteristics interviewed by these three instruments were also measured. The inter-rater agreement was assessed for evaluation of the coherence of the three scales. Transition rates of CAARMS, SIPS and BSABS for UCH+ subjects within 2 years were also recorded.There is good diagnostic agreement between the CAARMS, SIPS and BSABS towards identification of UHR subjects who are immediate family and three-generation blood kinship of patients with schizophrenia. Also, these three instruments are reliable and valid for assessing and detecting at risk mental states in these subjects.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-05-01
• Primary Completion: 2019-01-01
• Study Completion: 2021-04-01
• Status Verified: 2021-08
• Study First Submitted: 2021-08-31
• Study First Submitted QC: 2021-09-06
• Last Update Submitted: 2021-09-06
• Study First Posted: 2021-09-13
• Last Update Posted: 2021-09-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 189

Inclusion Criteria

• all are immediate family and three-generation blood kinship of patients with schizophrenia

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The overall agreement percent	2 years	diagnostic comparison of CAARMS and SIPS, SIPS and BSABS, CAARMS and BSABS.
the transition rates of UHR+ to psychosis within 2 years	2 years	Transition rates of CAARMS, SIPS and BSABS for UCH+ subjects within 2 years follow-up.
the inter-rater reliability	2 years	Inter-rater correlation (ICC) coefficients of CAARMS, SIPS and BSABS subscales.

Trial Locations

Locations (1)

Dept. of Psychological Rehabilitation, Affiliated Wuhan Mental Health Center, Tongji Medical College of Huazhong University of Science & Technology; 🇨🇳 Wuhan, Hubei, China