Effect of Metformin on Decrement in Levothyroxin Dose Required for Thyroid Stimulating Hormone (TSH) Suppression in Patients With Differentiated Thyroid Cancer

Not Applicable

Completed

• Conditions: Malignant Neoplasm of Thyroid Stage I; Malignant Neoplasm of Thyroid Stage II
• Interventions: Drug: Metformin

• Registration Number: NCT01341886
• Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary

Differentiated thyroid cancer is the most common neoplasm of endocrine system. After surgery and radioiodine treatment, thyroid stimulating hormone (TSH) suppression is the main goal which is achieved with levothyroxine treatment. Levothyroxine causes increased thyroid hormones which can have negative impact on bone and cardiovascular system. Anecdotal reports have shown that metformin can induce TSH suppression without change in T3 and T4 concentration. The purpose of this study was to prescribe metformin as additional drug to levothyroxin in order to decrease levothyroxine dosage.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-04
• Status Verified: 2011-04
• Primary Completion: 2011-04
• Study Completion: 2011-04
• Study First Submitted: 2011-04-18
• Study First Submitted QC: 2011-04-25
• Last Update Submitted: 2011-04-25
• Study First Posted: 2011-04-26
• Last Update Posted: 2011-04-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 51

Inclusion Criteria

• papillary or follicular thyroid cancer
• stage 1 or 2 according to TNM system version 6
• surgery and radioiodine treatment
• levothyroxine suppression treatment

Exclusion Criteria

• cardiopulmonary failure
• liver failure
• renal failure
• pregnancy
• drugs (colestyramin, sucralfate, phenobarbital, phenytoin, carbamazepin, rifampin, amiodarone, chloroquin, androgens, sertraline, frusemide, heparin)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
metformin	Metformin	patients who receive metformin in addition to levothyroxine
levothyroxine	Metformin	patients who receive only levothyroxine

Primary Outcome Measures

Name	Time	Method
TSH	3 months

Secondary Outcome Measures

Name	Time	Method
freeT3,freeT4	3months

Trial Locations

Locations (1)

Mashad University of Medical Sciences; 🇮🇷 Mashad, Khorasan Razavi, Iran, Islamic Republic of