Phase II study of gemcitabine and trastuzumab in patients with metastatic breast cancer
- Conditions
- Metastatic breast cancer
- Registration Number
- JPRN-UMIN000005881
- Lead Sponsor
- Setouchi Breast Project Comprehensive Organization
- Brief Summary
Background: There are few evidence on efficacy of Tmab-containing regimens after disease progression. Gemcitabine (GEM) is non-cross resistant to anthracycline and taxane. Preclinical studies have shown that the combination of Tmab and GEM has synergistic effect against HER2-positive breast cancer cell lines. SBP-01 study assessed the efficacy and safety of the combination of Tamb and GEM in patients with HER2-positive MBC previously treated with anti-HER2 therapy. Methods: SBP-01 study included patients treated with one or more anti-HER2 directed regimens for MBC. Patients were administered with GEM 1250 mg/m2 on days 1 and 8 of each 21-day cycle and Tmab 4mg/kg loading dose and then 2mg/kg weekly. The primary endpoint was objective response rate (ORR). Secondary endpoints included progression free survival (PFS), overall survival, and safety. Results: Between June 2011 and June 2014, 35 patients were enrolled. Patients had ER positive tumor (37.1%), a median of 2 metastatic organ sites, visceral metastasis (80.0%), prior (neo) adjuvant Tmab (22.9%) and a median of 2 prior chemotherapy regimens for MBC. Previous HER2-directed drugs included Tmab (94.3%), lapatinib (37.1%), T-DM1 (8.6%) and pertuzumab (2.9%). ORR was 22.9% (95% CI, 8.6%-36.8%). Median PFS was 146 days. Patients with stable disease response received a median of 7 cycles (6-28 cycles) of treatment. Grade3/4 leukopenia (20.0%) and neutropenia (48.6%) were observed. All non-hematological toxicities were less than grade3. Conclusions: The Combination Tmab and GEM is effective and well-tolerated regimen for patients previously treated with HER2-directed therapy, and appears to make disease stable for long time period.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Female
- Target Recruitment
- 42
Not provided
1) Active double cancer 2) Brain metastases that requiring treatment at registration 3) Unstable angina pectoris, congestive heart failure, myocardial infarction, or ventricular arrhythmia requiring medication within 6 months to registration 4) Uncontrolled hypertension or diabetes mellitus. 5) Active infection disease 6) Other severe, uncontrolled systemic disease 7) Over grade 3 hypersensitivity reaction to trastuzumab 8) Hormonal therapy, chemotherapy, or biological treatment <7days prior to registration 9) Radiation therapy <14days prior to registration 10) Prior gemcitabine therapy 11) Current pregnancy and lactation 12) Assessment by the investigator to be unsuitable to comply with the requirements of the protocol
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Objective response rate
- Secondary Outcome Measures
Name Time Method Progression free survival, Overall survival, Adverse events rate