Formulation and Evaluation of Nitroglycerin Aloe Vera Gel for Angina
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Efficacy of the 6% nitroglycerin aloe vera gel in relieving angina symptoms through topical administration.
研究概览
简要总结
We purchased Nitromint 2.6 mg tablet of Egis Pharmaceutical ltd. Hungary. I took Fresh aloevera leaves from plant and extracted the latex of aloevera 100 grams. I grinded 6.5 mg Nitro mint bypestle motor and added into 100 grams of aloevera gel mixed it with Robinson mixture for 15minutes per revolution under supervision of quality control test. This 6% nitroglycerin aloe vera gel is designed for topical application to patients with angina at CPEIC Multan. The gel will be applied to areas such as the chest or upper arms where it allows nitroglycerin to be absorbed through the skin producing vasodilation and increasing blood flow to the heart thereby relieving angina symptoms. Aloe vera contributes to skin soothing and healing reducing irritation at the application site. ECG monitors Pulse oximeter (lifecare:fingertip pulseoximeterchina) a thermometer (Hamilton company USA) a stethoscope and mercury manometer were used to record parameters like BP pulse rate blood pressure. Data will be composed after taking written informed consent 80 subjects meeting the eligibility criteria will be incorporated
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Outcome Assessor Blinded
入排标准
- 年龄范围
- 25.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •â€¢ Patient at least 25-60-year-old.
- •â€¢ Patient with suspected s angina pectoris who undergo coronary angiography • Breast feeding mothers • Intestinal angina • Hypertensive patient • Abdominal infarction • Pregnant female.
排除标准
- •â€¢ severe myocardial infarction • Cardiogenic shock • Severe heart faliure • Hypersensitive to medicine • Severe hypotension • Cardiac temponade.
结局指标
主要结局
Efficacy of the 6% nitroglycerin aloe vera gel in relieving angina symptoms through topical administration.
时间窗: baseline and after 4 hrs. | when angina settled
To assess the safety and tolerability of the gel.
时间窗: baseline and after 4 hrs. | when angina settled
To compare the onset and duration of action of the gel with other forms of nitroglycerin (e.g., sublingual tablets).
时间窗: baseline and after 4 hrs. | when angina settled
To evaluate patient compliance and usability of the gel.
时间窗: baseline and after 4 hrs. | when angina settled
To measure improvements in quality of life in patients with chronic angina.
时间窗: baseline and after 4 hrs. | when angina settled
次要结局
- Breathing pattern(Baseline & after 4 hrs)
研究者
Dr. Imran Ahmad Khan
Muhammad Institute of Medical and Allied Sciences, Multan, Pakistan.