Cardiovascular Status of Children 5 Years After Kawasaki Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 61
- 试验地点
- 2
- 主要终点
- Central blood pressure in children 5 years after KD
研究概览
简要总结
The aim of present study is to determine cardiovascular status of children who had KD in past and to identify possible biochemical markers of cardiovascular damage in those patients.
In this cross-sectional study children with history of KD will be examined 5 years after receiving intravenous immunoglobulin treatment (IVIG) and compared to healthy controls in terms of: serum levels of endothelial injury markers (circulating endothelial cells, galectin-3, soluble VCAM), peripheral blood pressure, central blood pressure, arterial stiffness parameters (measured by applanation tonometry), carotid intima media thickness (cIMT), capillaroscopy and echocardiography.
详细描述
All participants will be examined in Medical University Warsaw Children's Hospital.
Children with history of KD will be recruited from 2 paediatric hospitals in Warsaw and via advertisement by Polish support group for parents of children with KD in social media. Diagnosis of KD will be verified according to current American Heart Association (AHA) guidelines.
All children after KD will be examined 5 years after IVIG treatment exact to 2 months.
CAA presence at the time of KD diagnosis will be determined on the basis of medical records, after specialist consultation, in accordance to AHA definition. Worst-ever echocardiographic picture of coronary arteries will be considered in analysis.
Healthy age- and sex-matched controls (HC) will be recruited from KD patients' siblings.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 5 Years 至 15 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •history of KD treated with intravenous immunoglobulin (IVIG)
排除标准
- •any significant comorbidities,
- •body mass index (BMI) value > 1 standard deviation (SD) for age and gender,
- •height < 120 cm at the time of cardiovascular assessment.
研究组 & 干预措施
Kawasaki Disease (KD)
Children 5 years after Kawasaki Disease
Healthy controls (HC)
Age- and sexmatched healthy siblings of children after Kawasaki Disease
结局指标
主要结局
Central blood pressure in children 5 years after KD
时间窗: 5 years
comparison of central blood pressure values in KD and HC groups
Arterial stiffness in children 5 years after KD
时间窗: 5 years
comparison of pulse wave velocity Z-score in KD and HC groups
CEC in children 5 years after KD
时间窗: 5 years
comparison of CEC number in KD and HC groups
次要结局
- Diastolic function of the left ventricle in children 5 years after KD(5 years)
- VEGF in children 5 years after KD(5 years)
- Capillaroscopy in children 5 years after KD(5 years)
- Soluble E-selectin in children 5 years after KD(5 years)
- Endocan in children 5 years after KD(5 years)
- Thrombomodulin in children 5 years after KD(5 years)
- Left ventricle size in children 5 years after KD(5 years)
- cIMT in children 5 years after KD(5 years)
研究者
Magdalena Okarska-Napierała
Principal Investigator
Medical University of Warsaw