The Potential Value of Systemic Inflammation Response Index on Postoperative Delirium in Older Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 116
- 试验地点
- 1
- 主要终点
- CAM score
研究概览
简要总结
Postoperative delirium (POD) remains one of most common complication in elderly patients receiving surgery, which is characterized by acute and fluctuating change in the level of cognition and consciousness. Previous studies have shown that surgery and anesthesia-induced acute peripheral inflammation and neuroinflammation may lead to delirium after surgery. Systemic Inflammation Response Index (SIRI) is a more easily accessible and comprehensive inflammation marker derived from monocyte, neutrophil, and lymphocyte count, which has been investigated to assess the prognosis of cancer and infectious diseases. However, the relationship between SIRI and POD has yet to be investigated.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Hospital stay of at least 3 days
- •More than or equal to 65 years old
- •Elementary education or above
- •Able to communicate
- •American Society of Anesthesiologists (ASA) physical status I-III
- •Mini-mental State Examination (MMSE) scores ≥ 22 points
排除标准
- •Preoperative delirium
- •Severe mental diseases
- •Autoimmune-illness, chronic infectious diseases, nervous system diseases and malignancies
结局指标
主要结局
CAM score
时间窗: Postoperative day 3
Positive CAM score means that the patient developed postoperative delirium. While negative CAM score means that the patient did not develop postoperative delirium.
Confusion assessment method (CAM) score
时间窗: Baseline (Before surgery)
Positive CAM score means that the patient developed postoperative delirium. While negative CAM score means that the patient did not develop postoperative delirium.
次要结局
- MMSE score(postoperative day 3)
- Mini-mental State Examination (MMSE) score(Baseline (Before surgery))
- The level of systemic inflammation response index (SIRI) in peripheral blood.(Baseline (Before surgery))