The Potential Value of Systemic Inflammation Response Index on Postoperative Delirium in Older Patients
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Postoperative Delirium
- Sponsor
- Changhai Hospital
- Enrollment
- 116
- Locations
- 1
- Primary Endpoint
- CAM score
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Postoperative delirium (POD) remains one of most common complication in elderly patients receiving surgery, which is characterized by acute and fluctuating change in the level of cognition and consciousness. Previous studies have shown that surgery and anesthesia-induced acute peripheral inflammation and neuroinflammation may lead to delirium after surgery. Systemic Inflammation Response Index (SIRI) is a more easily accessible and comprehensive inflammation marker derived from monocyte, neutrophil, and lymphocyte count, which has been investigated to assess the prognosis of cancer and infectious diseases. However, the relationship between SIRI and POD has yet to be investigated.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Hospital stay of at least 3 days
- •More than or equal to 65 years old
- •Elementary education or above
- •Able to communicate
- •American Society of Anesthesiologists (ASA) physical status I-III
- •Mini-mental State Examination (MMSE) scores ≥ 22 points
Exclusion Criteria
- •Preoperative delirium
- •Severe mental diseases
- •Autoimmune-illness, chronic infectious diseases, nervous system diseases and malignancies
Outcomes
Primary Outcomes
CAM score
Time Frame: Postoperative day 3
Positive CAM score means that the patient developed postoperative delirium. While negative CAM score means that the patient did not develop postoperative delirium.
Confusion assessment method (CAM) score
Time Frame: Baseline (Before surgery)
Positive CAM score means that the patient developed postoperative delirium. While negative CAM score means that the patient did not develop postoperative delirium.
Secondary Outcomes
- MMSE score(postoperative day 3)
- Mini-mental State Examination (MMSE) score(Baseline (Before surgery))
- The level of systemic inflammation response index (SIRI) in peripheral blood.(Baseline (Before surgery))