Postoperative Delirium and Its Biomarkers in Elderly Patients Undergoing Non-cardiac and Non-neurosurgery: a Prospective Cohort Study.
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Anesthesia
- Sponsor
- Beijing Tiantan Hospital
- Enrollment
- 417
- Locations
- 1
- Primary Endpoint
- The incidence of postoperative delirium within postoperative 5 days
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
Postoperative delirium (POD) is a common complication in elderly patients and is associated with negative clinical outcomes, such as prolonged hospitalizations, cognitive impairment, and higher mortality rate. While the pathophysiology of delirium remains unknown, the cerebral hypoperfusion and neuroinflammatory response are considered to play an important role in the process of POD. The aim of the study is to determine the association between POD and biomarkers in elderly patients undergoing noncardiac and non-neurological surgery.
Investigators
Ruquan Han
Professor
Beijing Tiantan Hospital
Eligibility Criteria
Inclusion Criteria
- •With American Society of Anesthesiologists (ASA) physical status Ⅱ-Ⅳ
- •Undergo elective non-cardiac and non-neurological surgery receiving general anesthesia
- •Operation time is expected to be longer than 2 hours
Exclusion Criteria
- •Clinical diagnosis of dementia
- •Clinical diagnosis of cerebrovascular disorders
- •Clinical diagnosis of heart failure
- •Clinical diagnosis of liver failure
- •Clinical diagnosis of renal failure
- •Clinical diagnosis of traumatic brain injury
- •Alcohol abuse
- •Can not complete the cognitive assessments
- •Refuse to sign informed consent
Outcomes
Primary Outcomes
The incidence of postoperative delirium within postoperative 5 days
Time Frame: the incidence of delirum within postoperative 5 days.
The postoperative delirium will be diagnosed if patients have fluctuation in mental status and attention and either thinking or consciousness in the past 24 hours as evidenced by fluctuation on Confusion Assessment Method-Intensive Care Unit (CAM-ICU) scale.