A ckinical trial to study the effect of the three different low doses of intranasal dexmedetomidine in attenuation of hemodynamic responses to laryngoscopy.
Phase 2
Completed
- Conditions
- Health Condition 1: O- Medical and Surgical
- Registration Number
- CTRI/2021/09/036222
- Lead Sponsor
- DEPARTMENT OF ANAESTHESIA SPMC ASSOCIATED GROUP OF PBM HOSPITAL BIKANER
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
Patients with ASA Grade I & II
Exclusion Criteria
1.ASA >II
2.Predicted difficult airway with anticipated difficult intubation
3.Patient with nasal ulcer, polyp, nasal septum deviation
4. Allergy to any of used drugs
5.Patient with cardiac, renal, or hepatic dysfunction
6.Sinus bradycardia and heart block.
7.Patients on Ã?-blocker
8.Patients on calcium channel blocker
9.Pregnant and lactating women
10.Raised ICT(intra cranial tension)
11.Psychiatric patient
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Is to arrive at an optimal dose of intranasal dexmedetomidine by Comparing between three different low doses to attenuate stress response during laryngoscopy and endotracheal intubation.Timepoint: Comparision of haemodynamic parameter in pre operative and immediate post intubation period (SBP, DBP, MAP, Pulse rate, SpO2) between 3 groups from 40 min before induction at every 10 min interval till induction of anaesthesia, thereafter at 1min,5 min, and 10 min after intubation.
- Secondary Outcome Measures
Name Time Method To observe any side effects and complications related to drugs and procedure.Timepoint: at baseline