The Lymphocyte/Neutrophil Ratio as a Prognostic Index for Short Term Outcome in the ICU Admitted COVID-19 Adult Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- The Lymphocyte/neutrophil ratio
研究概览
简要总结
- ry outcome includes the correlation between lymphocyre /neurtophll ratio (LNR) and mortality rate during hospital stay in the ICU admitted COVID 19 patients.
- ry outcome(s) include the LNR and its correlation with ICU stay, the need for mechanical ventilation, renal impairment.
详细描述
In December 2019,the COVID-19 virus has been mainly breaking out in Wuhan in China as pneumonia affecting patients . Common clinical features During hospitalization started to appear including acute respiratory infection , inflammatory reaction , fever, pneumonia, cough, fatigue , anosmia .
The patient known suspected if he has a clinical picture of viral pneumonia, exposure history, and radiographic findings [CT] or [MRI] chest consistent with COVID-19 pneumonia. the gold standard and the Final diagnosis (PCR) positivity for the presence of coronavirus .
The immune response to respiratory infection causes neutrophils to collect inside the lung especially the alveoli. Neutrophils aggregation may lead to collateral tissue damage and cytotoxicity. According to Previous studies apoptosis of lymphocytes occurred due to the release of anti-inflammatory cytokines resulting in lymphopenia. high levels of circulating neutrophils have been demonstrated in COVID-19 patients(
A lot of literatures and studies have demonstrated the value of what is called neutrophil/ lymphocyte ratio (LNR) as a simple prognostic ratio correlated to morbidity and mortality. Up to our knowledge, there is no study utilized such ratio in COVID-19 ICU admitted patients, so that, this study has been built
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (aged ≥18 years)
- •Patients who need non-invasive ventilation (NIV or CPAP) or invasive ventilation (intubation)
排除标准
- •Previous diagnosis of severe liver or kidney failure.
- •Patients with Human Immunodeficiency Virus (HIV) infection.
- •Patients with previous hematological diseases (Leukemia) that condition alterations in blood counts.
- •Consumption of treatments with any type of immunosuppressants prior to admission that conditions low lymphocytes.
- •Patients with bone marrow depression.
结局指标
主要结局
The Lymphocyte/neutrophil ratio
时间窗: up to 30 days
The Lymphocyte/neutrophil ratio as a prognostic index for short term outcome in the ICU admitted COVID-19 adult patients
次要结局
未报告次要终点
研究者
Emad Zarief , MD
Professor Emad Zarief kamel
Assiut University