miRNA in Sweat, a Novel Digital Biomarker for Detection of Active Tuberculosis (TB)
- Conditions
- Active Tuberculosis
- Registration Number
- NCT05048381
- Lead Sponsor
- University Hospital, Basel, Switzerland
- Brief Summary
The detection of miRNA (non-coding ribonucleic acid) in the blood in the context of active tuberculosis is an innovative approach to the detection of new disease-specific biomarkers.
The primary goal of this analysis is to define, for the first time, an miRNA fingerprint for tuberculosis in sweat. Samples that were collected as part of the Sweatb Study (NCT03667742) project are examined for the occurrence of disease-specific, non-coding miRNAs to define new biomarkers in the sweat. These biomarkers can be detected non-invasively and will help in the detection of patients with active tuberculosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- Adult patients
- Ability to understand the purpose of the study, provide signed and dated informed consent by patient or his/her legal representative
- In-patients with acute tuberculosis, suspected tuberculosis or other pulmonary diseases (pneumonia, Bronchitis, COPD)
Inclusion criteria Healthy Donors:
- negative for Quantiferon- TB Gold Plus Test or ELISpot
- Written rejection of the consent for the further use of the data
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Detection of miRNA (non-coding ribonucleic acid) in blood Blood samples taken at baseline Analysis of blood protein markers in patients with active tuberculosis
Detection of miRNA (non-coding ribonucleic acid) in sweat Sweat samples taken at baseline Analysis of sweat protein markers in patients with active tuberculosis
- Secondary Outcome Measures
Name Time Method